Taking 2000 mg of a supplement called nicotinamide riboside every day for 5 to 10 weeks can boost energy-related molecules in the blood by more than double in people still dealing with long-term effects of COVID.

What we've found so far is that the evidence we've reviewed leans toward 2000 mg of nicotinamide riboside per day increasing markers related to energy production in people with long-COVID [1]. Our analysis of the available research shows this effect was observed over a period of 5 to 10 weeks. We looked at one key assertion from the data, which reports that this dose of nicotinamide riboside led to more than a doubling of certain energy-related molecules in the blood of individuals experiencing ongoing symptoms after COVID-19 [1]. These molecules are linked to NAD+, a compound involved in cellular energy and metabolism, though the evidence does not directly confirm NAD+ levels were measured or increased—only that related markers improved [1]. So far, all 66.0 supporting data points align with this finding, and we found no studies or assertions that contradict it. However, based on what we’ve reviewed so far, we can’t yet say how this change affects overall fatigue, recovery, or long-term health in these individuals. We also don’t have enough information to determine if the effects last beyond 10 weeks or if they apply to all long-COVID patients. Our current analysis is based on limited assertions—just one unique claim supported by multiple data points—and we recognize that new evidence could shift our understanding over time. Practical takeaway: If you're dealing with long-COVID, taking 2000 mg of nicotinamide riboside daily might influence energy-related pathways in the body, but we don’t yet know what that means for how you feel or recover.