Taking a supplement called nicotinamide riboside for about three months doesn’t make older people stronger or more physically able, and it might actually make physical performance a bit worse for those with mild memory issues.

What we've found so far is that nicotinamide riboside does not appear to improve physical performance in older adults, and there is some evidence it may slightly reduce physical ability in those with mild cognitive impairment [1]. Our analysis of the available research shows that after about three months of supplementation, no meaningful gains in strength or physical function were observed. We looked at one key assertion based on existing studies, which draws from 45.0 supporting data points and no studies that contradict it [1]. This means the evidence we’ve reviewed consistently points in the same direction—toward a lack of benefit for physical performance. In fact, for older individuals already experiencing mild memory issues, there may be a small decline in physical function when taking nicotinamide riboside [1]. It’s important to note that while the current evidence leans against a positive effect, we are still building our understanding. These findings don’t rule out possible benefits in other areas, such as cellular health or brain function, but when it comes to physical performance—like walking speed, balance, or muscle strength—the results we’ve reviewed so far do not show improvement. We don’t yet know whether longer use, different doses, or specific subgroups might change this picture. Our current analysis is limited to what has been studied and reported so far, and future research could shift our understanding. Practical takeaway: If you’re an older adult or caring for someone with mild cognitive concerns, taking nicotinamide riboside is unlikely to boost physical performance—and might slightly reduce it. This doesn’t mean the supplement has no value elsewhere, but for staying strong and mobile, the evidence we’ve seen doesn’t support expecting improvements.