Does a special vitamin help brain fog and tiredness after long COVID?
Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
NAD+ levels tripled, yet cognitive performance didn’t improve
Many assume boosting NAD+ should enhance brain function—especially in conditions like long-COVID tied to mitochondrial dysfunction. This disconnect challenges that assumption.
Practical Takeaways
Consider trying NR for long-COVID fatigue or brain fog—but track symptoms and be prepared for side effects.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
NAD+ levels tripled, yet cognitive performance didn’t improve
Many assume boosting NAD+ should enhance brain function—especially in conditions like long-COVID tied to mitochondrial dysfunction. This disconnect challenges that assumption.
Practical Takeaways
Consider trying NR for long-COVID fatigue or brain fog—but track symptoms and be prepared for side effects.
Publication
Journal
eClinicalMedicine
Year
2025
Authors
Chao-Yi Wu, W. Reynolds, Isabel Abril, A. McManus, Charles Brenner, Gabriel González-Irizarry, Leidys Gutiérrez-Martínez, Olivia Sun, Jonathan Rosand, Rudolph E. Tanzi, Steven Arnold, E. Guzmán-Vélez
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Claims (6)
Even though taking NR or NMN boosts a molecule called NAD+ in the blood, we don’t actually have solid proof it makes people stronger, healthier, sharper, or more energetic.
Taking 2000 mg of a supplement called nicotinamide riboside every day for 5 to 10 weeks can boost energy-related molecules in the blood by more than double in people still dealing with long-term effects of COVID.
Taking a supplement called nicotinamide riboside every day for up to 20 weeks doesn't seem to help improve thinking skills in adults who are still dealing with long-term effects from COVID-19.
Taking 2000 mg of nicotinamide riboside every day for 10 weeks might help people with long-COVID feel a little better in terms of thinking clearly, feeling less tired, sleeping better, and feeling less down.
Taking 2000 mg of nicotinamide riboside every day might be hard for people with long-COVID because more than half stopped taking it within 20 weeks, mostly because they felt worse or got sick again.