Oral supplementation with a nonliposomal formulation containing 50 mL/day of fish-derived collagen tripeptides, yeast extract, hyaluronic acid, and resveratrol for 8 weeks improves skin elasticity and hydration in healthy adults aged 25–65 and does not significantly reduce wrinkle area.

When you swallow collagen tripeptides, they survive digestion and enter the bloodstream. They reach the skin and tell fibroblast cells to make more collagen and elastin, which are the structural fibers that keep skin firm and stretchy. At the same time, the supplement increases the skin’s natural hyaluronic acid, which holds water and plumps the skin. This makes the skin more elastic and hydrated, but the amount of new fiber growth is not enough to smooth out deep wrinkles.