The Study
Liposomal Delivery Enhances the Effects of a Collagen Tripeptide–Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double‐Blind, Placebo‐Controlled Trial
This study is like a fair test where people got either a special drink, a regular drink, or a fake drink — and scientists measured their skin before and after. They found the special drink made skin look better, but only for the people who drank it for 8 weeks. We can't say it will work for everyone or forever.
Analysis score
Maximum 45 for a randomized controlled trial.
Where the score came from
Scientists tested two kinds of collagen drinks: one with tiny protective bubbles (liposomal) and one without. Both helped skin, but the bubbly one worked faster and better.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 545 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — wrinkles decreased and skin looked brighter and tighter, which people can see and feel in daily life.
- 2After 8 weeks: both drinks improved skin hydration, elasticity, and brightness; only the bubbly drink reduced wrinkles and improved elasticity more than the plain one.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Journal of Cosmetic Dermatology
Year
2026
Authors
Yung-Kai Lin, Chia-Hua Liang, Ban‐Chin Huang, Sze‐Huey Lim, Yung-Hsiang Lin, S. Chan, Chi-Fu Chiang, Yi-Wen Mao
Related Content
Claims (6)
Taking collagen peptide supplements by mouth increases skin hydration and elasticity in humans.
Taking a daily oral supplement containing fish-derived collagen tripeptides, yeast extract, hyaluronic acid, and resveratrol for 8 weeks increases dermal collagen density and skin hydration in healthy adults aged 25–65 compared to a placebo.
Taking a specific liposomal supplement containing fish-derived collagen tripeptides, yeast extract, hyaluronic acid, and resveratrol daily for 8 weeks increases skin luminance and tone evenness in healthy adults aged 25–65 compared to a placebo.
Taking a specific liposomal supplement containing fish-derived collagen tripeptides, yeast extract, hyaluronic acid, and resveratrol daily for 8 weeks increases skin elasticity and decreases wrinkle area in healthy adults aged 25–65 more than a similar supplement without liposomal encapsulation.
Oral collagen tripeptides delivered in liposomes improve skin elasticity and hydration sooner than collagen tripeptides delivered without liposomes in healthy adults aged 25–65 over 8 weeks.
Taking a daily oral supplement containing 50 mL of a mixture of fish-derived collagen tripeptides, yeast extract, hyaluronic acid, and resveratrol for 8 weeks increases skin elasticity and hydration in healthy adults aged 25–65, without significantly reducing wrinkle area.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.