Tesamorelin is a drug that tells the body to make more of its own growth hormone in a natural way, rather than giving the body extra growth hormone directly.
Scientific Claim
Tesamorelin is a growth hormone-releasing hormone analog that stimulates the pituitary gland to produce endogenous growth hormone in a physiologically appropriate pattern, as opposed to exogenous growth hormone administration.
Original Statement
“So tesamorelin is a growth hormone releasing hormone analog. So, what that means is it tells your pituitary gland to produce more of your own growth hormone. Okay? So, in a physiological pattern that makes sense, the way your body should release it, not like exogenous growth hormone where you're just blasting yourself with a bunch of it.”
Context Details
Domain
pharmacology
Population
human
Subject
tesamorelin
Action
stimulates
Target
endogenous growth hormone production in a physiological pattern
Intervention Details
Evidence from Studies
Supporting (2)
The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV
This study shows that tesamorelin works as expected to improve muscle in people with HIV, which aligns with how it's supposed to work by helping the body make its own growth hormone.
This study looks at how light affects plant growth hormones, which isn't directly related to tesamorelin but shows research in the area of hormone effects.
Contradicting (1)
Effects of Tesamorelin on Neurocognitive Impairment in Abdominally Obese Persons with HIV.
This study found that tesamorelin didn't show clear benefits for brain function in people with HIV who are obese, which doesn't support the idea that it works well for everyone.