The cellular cleanup system called the proteasome is more active in people having a heart attack compared to those with stable heart disease, which might be related to the body's response to the heart attack.

Scientific Claim

Proteasome activity is significantly higher in ST-elevation myocardial infarction (STEMI) patients compared to chronic coronary syndrome (CCS) patients (3.788 ± 1.078 vs. 2.372 ± 1.327; p < 0.001), suggesting increased protein degradation capacity in acute coronary events.

Original Statement

“Proteasome activity was higher in STEMI as compared to CCS patients (STEMI vs. CCS 3.788 ± 1.078 vs. 2.372 ± 1.327; p < 0.001), and a significant inverse correlation was evident between PLIN2 levels and proteasome activity in the CCS group (p = 0.018), while it was not significant in the STEMI group (Figure 3C,D).”

From study:Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and shows a difference between groups. The claim uses 'suggesting increased protein degradation capacity in acute coronary events' which appropriately reflects the observational nature of the study.

Evidence from Studies

Supporting (1)

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Cross-Sectional Study

Human

Contradicting (0)

No contradicting evidence found

Source Study

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Score: 37

DOI: 10.3390/ijms26199550

Similar Assertions

In people with stable heart disease, when the proteasome (cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack, suggesting different ways PLIN2 is regulated in these two conditions.

86%

In people with stable heart disease, when the proteasome (a cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack.

82%

In people having a heart attack, PLIN2 protein stays high even though the cellular cleanup system (proteasome) is more active, suggesting there might be special reasons why PLIN2 isn't being broken down properly during a heart attack.

78%