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Back to Study: Effect of Once-Weekly Exenatide in Patients With T...
quantitative
Analysis v1
Strong Support

If you have type 2 diabetes and already have heart failure, the weekly diabetes shot exenatide might not help you live longer or keep you out of the hospital for heart problems. But if your heart is healthy, it could lower your risk of dying by 21%.

95
Pro
0
Against

Evidence from Studies

Supporting (1)

95

Community contributions welcome

95

Effect of Once-Weekly Exenatide in Patients With Type 2 Diabetes With and Without Heart Failure and Heart Failure-Related Outcomes: Insights From the EXSCEL Trial.

Randomized Controlled Trial
Human
2019 Nov 12

The study found that a diabetes drug called exenatide helped lower the risk of death in people without heart failure, but not in those who already had heart failure, which supports the claim.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effect of Once-Weekly Exenatide in Patients With Type 2 Diabetes With and Without Heart Failure and Heart Failure-Related Outcomes: Insights From the EXSCEL Trial.

Score: 95
DOI: 10.1161/CIRCULATIONAHA.119.041659

Similar Assertions

Taking a weekly diabetes shot called exenatide may help lower the chance of dying or ending up in the hospital with heart failure for people with type 2 diabetes.

95
0
91%

Taking a weekly diabetes shot called exenatide doesn’t stop the first heart failure hospital stay, but it does cut down on how often people end up back in the hospital for heart problems by about 18%.

95
0
88%

A weekly diabetes shot called exenatide doesn’t lower the chance of ending up in the hospital for heart failure for the first time in people with type 2 diabetes — it’s basically neutral, even though it might help if someone already has heart issues.

95
0
87%

A weekly diabetes shot called exenatide may help people with type 2 diabetes live longer, especially if they don’t already have heart failure.

95
0
80%

For people with type 2 diabetes and healthy kidneys, taking a weekly exenatide shot might slightly lower the risk of heart problems or dying, but the evidence isn't strong and hasn't been fully checked for other factors.

82
0
70%