The Claim

Efavirenz inhibits mitochondrial complex I activity in isolated mouse liver mitochondria with an IC50 of approximately 30 μM, and this inhibition alone does not cause hepatocyte injury but primes cells for toxicity when combined with isoniazid.

Source: Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
12score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

A drug called efavirenz can block a key energy process in mouse liver cells at a specific dose, and while it doesn’t hurt the cells by itself, it makes them much more likely to get damaged when combined with another drug called isoniazid.

See the scientific wording

Efavirenz inhibits mitochondrial complex I activity in isolated mouse liver mitochondria with an IC50 of approximately 30 μM, and this inhibition alone does not cause hepatocyte injury but primes cells for toxicity when combined with isoniazid.

What the research says

1 study

  1. Study: Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

    Efavirenz alone doesn't hurt liver cells, but when taken with isoniazid, they team up to damage mitochondria—the cell's power plants—causing toxic stress. The study proves this combo is dangerous because it breaks the energy system in a way that only happens when both drugs are present.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

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