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Back to Study: Methylene blue does not bypass Complex III antimyc...
quantitative
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Strong Opposition

The more methylene blue you add, the more hydrogen peroxide the mitochondria make—up to 25 times more at the highest dose tested.

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Pro
10
Against

Evidence from Studies

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No supporting evidence found

Contradicting (1)

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10

Methylene blue does not bypass Complex III antimycin block in mouse brain mitochondria

Cohort Study
Animal
2019 Mar

The study says methylene blue only makes hydrogen peroxide if another part of the cell’s energy system (Complex III) is working — and it doesn’t show that more methylene blue means more peroxide, so it doesn’t back up the claim.

Source Study

Methylene blue does not bypass Complex III antimycin block in mouse brain mitochondria

Score: 10
DOI: 10.1002/1873-3468.13332

Similar Assertions

Methylene blue makes mitochondria produce more hydrogen peroxide, but if you block a specific part of the energy chain (Complex III), that extra production stops—meaning methylene blue needs that part to work.

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83%

Methylene blue makes heart cell power plants produce more harmful molecules when using one fuel (glutamate/malate), but less when using another (succinate), showing its effect depends on what the cell is burning.

10
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78%

Methylene blue helps brain cells use oxygen more efficiently to make energy after they’ve been starved.

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78%

Unlike some toxins, methylene blue doesn’t make harmful free radicals in brain cells after they’ve been starved.

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77%

After brain cells are starved and then get oxygen and sugar back, methylene blue helps them make more of their main energy molecule.

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76%