Methylene blue makes mitochondria produce more hydrogen peroxide, but if you block a specific part of the energy chain (Complex III), that extra production stops—meaning methylene blue needs that part to work.

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Evidence from Studies

Supporting (1)

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Methylene blue does not bypass Complex III antimycin block in mouse brain mitochondria

Cohort Study

Animal

2019 Mar

The study shows that methylene blue makes brain mitochondria produce more hydrogen peroxide, but only if a key part of the energy system (Complex III) is working; if you block that part, the hydrogen peroxide stops, meaning methylene blue needs that part to work, not some other route.

Contradicting (0)

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No contradicting evidence found

Source Study

Methylene blue does not bypass Complex III antimycin block in mouse brain mitochondria

Score: 10

DOI: 10.1002/1873-3468.13332

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