The muscle energy recovery speed (ViPCr) responded more clearly to IGF-I than another measure (τPCr), meaning ViPCr might be a better way to track how well muscles are making energy.
Scientific Claim
In obese adults with reduced GH, the correlation between IGF-I increase and phosphocreatine recovery was stronger for the mitochondrial parameter ViPCr (R=0.56) than for τPCr (R=−0.42), suggesting ViPCr is a more sensitive marker of mitochondrial response to IGF-I.
Original Statement
“Univariate regression analysis among all evaluable paired MRS data (n = 20 pairs) revealed a significant positive relationship between increases in IGF-I and improvements in ViPCr (R=0.56; P=.01) and similarly, increases in IGF-I trended toward significance in relationship to improvement in τPCr (R=−0.42; P=.07).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The comparison of correlation coefficients and P-values is accurately reported. The language 'stronger' and 'trended toward significance' appropriately reflects the statistical evidence.
Evidence from Studies
Supporting (1)
The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.
The study found that when obese people with low growth hormone got more IGF-I, their muscle energy recovery got better—and this improvement was strongly linked to a specific measure called ViPCr, which shows how well mitochondria work.