Even when accounting for factors like age, weight, and insulin levels, higher IGF-I still links to better muscle energy recovery in obese people with low growth hormone.
Scientific Claim
After adjusting for age, sex, race, ethnicity, body composition, and insulin sensitivity parameters, the association between increases in insulin-like growth factor I (IGF-I) levels and improvements in phosphocreatine recovery rate (ViPCr) remains statistically significant (all P<0.05) in obese adults with reduced GH secretion.
Original Statement
“This association remained significant after controlling for age, sex, race, ethnicity, and parameters of body composition and insulin sensitivity (all P<.05).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design supports correlational claims with adjustment for confounders. The language 'remains statistically significant' accurately reflects the multivariate analysis results.
Evidence from Studies
Supporting (1)
The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.