Even when accounting for factors like age, weight, and insulin levels, higher IGF-I still links to better muscle energy recovery in obese people with low growth hormone.
Scientific Claim
After adjusting for age, sex, race, ethnicity, body composition, and insulin sensitivity, increases in insulin-like growth factor I (IGF-I) levels remain significantly associated with improvements in phosphocreatine recovery rate (ViPCr) in obese adults with reduced growth hormone secretion (all P<0.05).
Original Statement
“This association remained significant after controlling for age, sex, race, ethnicity, and parameters of body composition and insulin sensitivity (all P<.05).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study used statistical adjustment, but the relationship remains correlational. 'Associated' is correct.
Evidence from Studies
Supporting (1)
The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.
This study found that when obese people with low growth hormone got a treatment that raised their IGF-I levels, their muscles recovered energy faster after exercise — and this link stayed strong even after accounting for things like age, weight, and insulin levels.