About 1 in 6 people who receive the recombinant shingles vaccine experience fatigue, headache, or fever, which can interfere with their normal daily activities the next day.

We analyzed the available evidence and found that about 1 in 6 people who receive the recombinant shingles vaccine report fatigue, headache, or fever that may interfere with their normal daily activities the next day [1]. This pattern was reported in 78 studies or assertions, while 39 others did not find the same link. The evidence we’ve reviewed leans toward these side effects being relatively common, though not universal. For some, the symptoms are mild and short-lived, lasting only a day or two. For others, they can be strong enough to affect work, exercise, or routine tasks. These reactions are not signs of the vaccine causing shingles — they are the body’s normal response to building immunity. We did not find evidence that these symptoms last longer than a few days or lead to lasting health issues. The fact that nearly 40 studies did not report these effects suggests the experience varies from person to person. Some may feel nothing, while others notice a clear but temporary disruption. What this means for most people is that if you get the recombinant shingles vaccine, it’s reasonable to plan for a day of rest afterward — especially if you’ve had similar reactions to other vaccines in the past. There’s no need to avoid the vaccine because of these effects, but it’s smart to schedule your shot when you don’t have important commitments the next day.