The Claim

Daily administration of 100 mg enteric-coated aspirin to healthy adults aged 70 years and older results in a progressive, linear increase in major hemorrhage risk over time, with no evidence of risk reduction or protective adaptation during prolonged therapy.

Source: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
88score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

Taking a daily 100 mg aspirin as you get older doesn't stop your risk of serious bleeding from going up over time. Instead of your body getting used to it and the risk going down, the chance of bleeding keeps steadily climbing the longer you take it.

See the scientific wording

The risk of major hemorrhage associated with daily 100 mg enteric-coated aspirin use in healthy adults aged 70 years and older remains constant over time and does not decline with prolonged therapy. Cumulative incidence analysis over a median follow-up of 4.7 years demonstrates a progressive, linear increase in bleeding events in the aspirin group compared to placebo, indicating that the bleeding risk persists throughout the entire duration of treatment without a protective adaptation or waning effect.

What the research says

1 study
  1. Study: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly

    Longitudinal follow-up data tracked cumulative incidence over 4.7 years. The consistent separation of curves between groups demonstrates a persistent, non-declining hazard ratio for bleeding.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.