The same body response that helps you survive famine might also cause the brain energy problems and inflammation seen in early Alzheimer’s.

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Evidence from Studies

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Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?

Narrative Review

2023 Mar

This study suggests that too much fructose (like sugar) might trick the brain into thinking it’s starving, causing it to slow down energy use and create problems that look like Alzheimer’s—so the claim that fructose could be linked to these early brain changes is backed by this idea.

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Source Study

Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?

Score: 1

DOI: 10.1016/j.ajcnut.2023.01.002

Similar Assertions

What used to help humans survive famines—slowing down metabolism and storing fat—might now be causing Alzheimer’s because we’re always eating sugar and never getting a break.

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Eating too much sugar, white bread, or salty food might trick your body into thinking it’s starving, which could over time harm your brain and raise Alzheimer’s risk.

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When your body detects low food supply, it switches to a survival mode by using fructose to slow down your metabolism and store energy, so your brain gets more sugar.

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If this theory is right, cutting sugar or taking a pill that blocks fructose might help stop or slow Alzheimer’s—but we don’t know yet.

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