Supported
mechanistic
Your muscles grow bigger mainly because of how much total force they feel over time—not whether you do your workouts all at once or spread out over the week.
54
38
Evidence from Studies
Supporting (4)
54
Community contributions welcome
54
Effect of different training frequencies on maximal strength performance and muscle hypertrophy in trained individuals—a within-subject design
Randomized Controlled Trial
Human
202238
Equalization of Training Protocols by Time Under Tension Determines the Magnitude of Changes in Strength and Muscular Hypertrophy
Randomized Controlled Trial
Human
2022 Jul 11
Load-induced human skeletal muscle hypertrophy: Mechanisms, myths, and misconceptions
Narrative Review
2025 Nov 21Contradicting (2)
38
Community contributions welcome
38
A Comparison Between Synergist and Nonsynergist Resistance Training Schemes in Recreationally Trained Men.
Randomized Controlled Trial
Human
2025 Dec 12Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.