mechanistic
Analysis v1
Strong Support
Fat cells found deeper in the belly (visceral) have more cortisol receptors than fat cells under the skin (subcutaneous), so they respond more strongly to the stress hormone cortisol by taking in more fat and growing faster.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue.
Cross-Sectional Study
Human
2010 OctThe study looked at gene expression in fat tissue from women's bellies and hips. It found that the belly fat (visceral/omental) has more glucocorticoid receptor genes than hip fat (subcutaneous). This matches part of the claim about higher receptor density in visceral fat. However, the study didn't test whether this actually causes more fat storage or cell growth.
Contradicting (0)
0
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No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.