The Claim
Supraphysiological intravenous infusion of arginine vasopressin (AVP) at 112.3 pmol/L increases plasma glucose by approximately 0.8 mmol/L in healthy adults without altering insulin, and this effect is mediated by glucagon-mediated glycogenolysis in the liver.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
A high-dose intravenous infusion of arginine vasopressin raises blood glucose levels by about 0.8 mmol/L in healthy adults without changing insulin levels, and this increase is caused by glucagon triggering the breakdown of glycogen in the liver.
See the scientific wording
Supraphysiological intravenous infusion of arginine vasopressin (AVP) at 112.3 pmol/L increases plasma glucose by approximately 0.8 mmol/L in healthy adults without altering insulin, suggesting AVP may directly stimulate hepatic glucose production via glucagon-mediated glycogenolysis.
A high dose of the hormone AVP binds to receptors on pancreatic cells that produce glucagon, causing those cells to release more glucagon. The glucagon then travels to the liver and triggers the breakdown of stored sugar into glucose, which is released into the blood, raising blood sugar levels without changing insulin.
What the research says
1 studyStudy: Hydration, Arginine Vasopressin, and Glucoregulatory Health in Humans: A Critical Perspective
When scientists injected a high dose of the hormone AVP into people’s veins, their blood sugar went up by about 0.8 mmol/L — just like the claim says. This happened because AVP triggered the liver to release stored sugar, likely through another hormone called glucagon.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.