The Claim
Vasopressin stimulates hepatic gluconeogenesis, resulting in increased endogenous glucose production.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Vasopressin increases the liver's production of glucose from non-sugar sources.
See the scientific wording
Vasopressin stimulates hepatic gluconeogenesis, increasing endogenous glucose production.
Vasopressin binds to liver cells and causes a surge in calcium inside them, which turns on enzymes that break down stored sugar and block enzymes that use sugar for energy. This forces the liver to release more glucose into the blood. Cortisol from the adrenal glands keeps this process running strongly.
What the research says
3 studiesStudy: Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men
This study found that higher levels of a hormone related to vasopressin are linked to a higher chance of developing diabetes, even when accounting for other risk factors. This suggests vasopressin may be making the liver produce more sugar.
This study shows that vasopressin tells the liver to break down stored sugar and make more new sugar, even without using the usual signals. This means vasopressin helps the liver produce more glucose, just like the claim says.
Study: The control by vasopressin of carbohydrate and lipid metabolism in the perfused rat liver.
This study showed that when vasopressin is added to a rat's liver in a lab dish, the liver releases more glucose — meaning it's making sugar from non-sugar stuff, like proteins or fats. So yes, vasopressin helps the liver make more glucose.
Related videos
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 3 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.