Analysis Version
v1
History
Back to Study: Ketone body 3-hydroxybutyrate elevates cardiac out...
causal
Analysis v1
14
Pro
0
Against

When added to isolated rat hearts, a ketone body made the heart muscle contract more strongly and increased blood flow to the heart muscle itself.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The isolated heart experiments with controlled interventions support definitive causal language for the specific experimental conditions.

Evidence from Studies

Supporting (1)

14
14

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Randomized Controlled Trial
Animal
2023 Sep 9

Contradicting (0)

0
No contradicting evidence found

Source Study

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Score: 14
DOI: 10.1007/s00395-023-01008-y

Similar Assertions

In rat hearts outside the body, butyrate at a certain dose made the heart pump harder, increasing pressure by 14.1%.

17
0
72%

In rats, a specific dose of a ketone body made the heart pump more blood per beat and overall without changing how fast the heart beats.

14
0
70%