quantitative
Analysis v1
17
0
In rat hearts outside the body, butyrate at a certain dose made the heart pump harder, increasing pressure by 14.1%.
Scientific Claim
In rats, butyrate at 0.5 mM was associated with a 14.1% increase in left ventricular systolic pressure in isolated perfused hearts compared to control.
Original Statement
“0.5 mM butyrate increased left ventricular systolic pressure by 14.1±4.1% in isolated perfused hearts.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal model with no human data, so 'associated with' is correct. The verb strength is appropriate as the study design (animal cohort) cannot establish causation.
Evidence from Studies
Supporting (1)
17
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Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties
Randomized Controlled Trial
Animal
2024 May 7Contradicting (0)
0
No contradicting evidence found