In rats, giving butyrate at a certain concentration made the heart pump 48.8% more blood without changing blood pressure or heart rate.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is an animal model with no human data, so 'associated with' is correct. The verb strength is appropriate as the study design (animal cohort) cannot establish causation.

Evidence from Studies

Supporting (1)

17

Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties

Randomized Controlled Trial

Animal

2024 May 7

Contradicting (0)

0

No contradicting evidence found

Source Study

Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties

Score: 17

DOI: 10.1161/JAHA.123.033744

Similar Assertions

In rat hearts, butyrate at a higher dose increased blood flow through the heart's arteries by 20.9%.

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In rats, butyrate made blood vessels wider, reducing resistance by 33.5% without changing blood pressure or heart rate.

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In rat hearts outside the body, butyrate at a certain dose made the heart pump harder, increasing pressure by 14.1%.

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In rats, butyrate caused blood vessels in the heart to relax more as the dose increased, with the most effective dose being 0.57 mM.

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