In rats, butyrate caused blood vessels in the heart to relax more as the dose increased, with the most effective dose being 0.57 mM.

In rat hearts, butyrate at a higher dose increased blood flow through the heart's arteries by 20.9%.

In rats, giving butyrate at a certain concentration made the heart pump 48.8% more blood without changing blood pressure or heart rate.

In rats, butyrate made blood vessels wider, reducing resistance by 33.5% without changing blood pressure or heart rate.