quantitative
Analysis v1
17
0
In rats, butyrate caused blood vessels in the heart to relax more as the dose increased, with the most effective dose being 0.57 mM.
Scientific Claim
In rats, butyrate induced concentration-dependent relaxation of coronary arteries with an EC50 of 0.57 mM.
Original Statement
“Butyrate relaxed isolated coronary septal arteries concentration dependently with an EC50=0.57 mM (95% CI, 0.23–1.44).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal model with no human data, so 'associated with' is correct. The verb strength is appropriate as the study design (animal cohort) cannot establish causation.
Evidence from Studies
Supporting (1)
17
17
Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties
Randomized Controlled Trial
Animal
2024 May 7Contradicting (0)
0
No contradicting evidence found