quantitative
Analysis v1
17
0
In rats, butyrate made blood vessels wider, reducing resistance by 33.5% without changing blood pressure or heart rate.
Scientific Claim
In rats, butyrate administration at 0.56 mM was associated with a 33.5% reduction in systemic vascular resistance without affecting mean arterial pressure or heart rate.
Original Statement
“lowered systemic vascular resistance by 33.5±6.4% without affecting blood pressure or heart rate in vivo.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal model with no human data, so 'associated with' is correct. The verb strength is appropriate as the study design (animal cohort) cannot establish causation.
Evidence from Studies
Supporting (1)
17
17
Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties
Randomized Controlled Trial
Animal
2024 May 7Contradicting (0)
0
No contradicting evidence found