Butyrate boosts heart function in rats
Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Increased cardiac output without raising blood pressure or heart rate
Typically, boosting heart output would spike blood pressure, but butyrate simultaneously relaxed blood vessels enough to keep BP stable.
Practical Takeaways
Eat more fiber-rich foods (e.g., oats, beans, bananas) to boost natural butyrate production by gut bacteria.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Increased cardiac output without raising blood pressure or heart rate
Typically, boosting heart output would spike blood pressure, but butyrate simultaneously relaxed blood vessels enough to keep BP stable.
Practical Takeaways
Eat more fiber-rich foods (e.g., oats, beans, bananas) to boost natural butyrate production by gut bacteria.
Publication
Journal
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Year
2024
Authors
J. Seefeldt, C. Homilius, Jakob Hansen, T. Lassen, N. R. Jespersen, R. Jensen, E. Boedtkjer, H. Bøtker, R. Nielsen
Related Content
Claims (8)
Blood pressure is determined by cardiac output, blood volume, and vascular resistance; an increase in any of these factors elevates blood pressure.
In rats, giving butyrate at a certain concentration made the heart pump 48.8% more blood without changing blood pressure or heart rate.
In rat hearts outside the body, butyrate at a certain dose made the heart pump harder, increasing pressure by 14.1%.
In rats with heart injury from blocked blood flow, butyrate at a certain dose reduced the damaged heart tissue by 81.7%.
In rats, butyrate caused blood vessels in the heart to relax more as the dose increased, with the most effective dose being 0.57 mM.