The Claim
Long-term severe dietary carbohydrate restriction in adults causes secondary disaccharidase deficiency through the downregulation of small intestinal brush-border enzyme production in response to chronically low substrate availability.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Eating very few carbs for a long time might cause your small intestine to stop making enough digestive enzymes, because it adjusts to the lack of food it normally breaks down.
See the scientific wording
Secondary disaccharidase deficiency can occur as a consequence of long-term severe dietary carbohydrate restriction in adults, indicating that the small intestine may downregulate enzyme production when substrate availability is chronically low. This adaptive or pathological response highlights the dynamic nature of intestinal brush-border enzymes and their dependence on dietary composition for maintenance of normal activity levels.
What the research says
1 studyCutting carbs severely for a long time can cause your gut to stop making enough enzymes to digest sugars, showing that your intestines adjust their enzyme production based on what you eat.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.