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Strong Support
correlational
Analysis v3
History

In adults with obesity and prediabetes, reducing intake of simple sugars and carbohydrates during calorie restriction is linked to a 35.4% improvement in a measure of insulin resistance called...

82
Pro
0
Against

Mechanism

Synthesis from 1 study

How it works

Eating less sugar and white flour means the liver makes less fat. Less fat in the liver lets insulin work properly to remove sugar from the blood. This lowers insulin levels and improves blood sugar control.

Most probable mechanism

In Simple Terms

When people eat less sugar and white flour, the liver makes less fat, which lets insulin work better to pull sugar out of the blood, lowering blood sugar levels.

Causal chain
1

Reduced intake of simple carbohydrates and added sugars decreases hepatic de novo lipogenesis

Supported by evidence
which leads to
2

Lower hepatic lipid accumulation reduces diacylglycerol and ceramide deposition in hepatocytes

Supported by evidence
which leads to
3

Decreased intracellular lipid metabolites restore insulin receptor substrate-1 phosphorylation and Akt activation

Supported by evidence
which leads to
4

Improved hepatic insulin signaling suppresses gluconeogenesis and enhances glycogen synthesis

Supported by evidence
which leads to
5

Reduced hepatic glucose output and enhanced peripheral glucose uptake lower fasting insulin and glucose concentrations

Supported by evidence

Evidence from Studies

Supporting (1)

82

Community contributions welcome

82

Effect of the glucagon-like peptide-1 receptor agonist liraglutide, compared to caloric restriction, on appetite, dietary intake, body fat distribution and cardiometabolic biomarkers: A randomized trial in adults with obesity and prediabetes

Randomized Controlled Trial
Human
2023 Aug

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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Source Study

Effect of the glucagon-like peptide-1 receptor agonist liraglutide, compared to caloric restriction, on appetite, dietary intake, body fat distribution and cardiometabolic biomarkers: A randomized trial in adults with obesity and prediabetes

Score: 82
DOI: 10.1111/dom.15113

Similar Assertions

In middle-aged people who are overweight, eating fewer carbs and more fat for 15 weeks might help their body respond better to insulin, while cutting calories on a low-fat diet could actually make insulin work worse — and these changes happen even if both groups lose about the same amount of weight.

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46
82%

In people with type 2 diabetes, eating diets high in monounsaturated fats or high in carbohydrates can lead to better insulin sensitivity, mainly because these diets cause weight loss, not because of the specific types of fats or carbs consumed.

63
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If you're middle-aged and your body doesn't respond well to insulin, cutting carbs and eating more fat might help you lose belly fat better than a low-fat diet. But if your body handles insulin normally, both diets work about the same for fat loss.

46
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In people with obesity and prediabetes, losing weight through diet improves how the liver responds to insulin, but does not improve how muscles and other tissues respond to insulin.

0
0
75%

Eating a low-carb diet for 12 weeks helps people with type 2 diabetes and obesity improve how their liver responds to insulin, making it work better without needing to change their medications.

60
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