Ames dwarf mice that eat 30% less food than normal have an 87% survival rate at 2.25 years, while those that eat without restriction have a 54% survival rate at the same age.
Mechanism
Synthesis from 1 study
These mice are born with a slow metabolism and low growth signals, which already helps them live longer. When they eat less, their bodies make even less of the signals that tell cells to grow and use energy. This slows down damage inside their cells, keeps their body cooler, and helps them stay...
Most probable mechanism
When these mice eat less food, their bodies produce less insulin and IGF-1, which slows down cell growth and repair processes. This reduces damage from energy use, lowers body temperature, and keeps the body running more efficiently. The mice also move more, which helps maintain muscle and brain function. Together, these changes delay aging and let more mice live longer.
Reduced food intake lowers circulating glucose and insulin levels
Lower insulin signaling reduces activation of the mTOR pathway and increases activity of sirtuin and FOXO transcription factors
Reduced insulin and growth hormone signaling decreases hepatic production of insulin-like growth factor 1 (IGF-1)
Lower IGF-1 and insulin levels reduce cellular proliferation and anabolic drive, slowing accumulation of molecular damage
Metabolic rate decreases and core body temperature drops, reducing oxidative stress and macromolecular damage
Increased locomotor activity preserves neuromuscular function and cognitive performance
Delayed onset of age-related pathologies, including tumors, extends functional lifespan
Evidence from Studies
Supporting (1)
Community contributions welcome
Studies of aging in ames dwarf mice: Effects of caloric restriction
Contradicting (0)
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