Why do tiny mice live longer?
Studies of aging in ames dwarf mice: Effects of caloric restriction
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists studied tiny mice with a special gene that makes them live longer. They gave some of them less food to see if that made them live even longer.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 513 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists studied tiny mice with a special gene that makes them live longer. They gave some of them less food to see if that made them live even longer.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 513 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Mattison JA, Wright C, Bronson RT, Roth GS, Ingram DK, Bartke A
Related Content
Claims (6)
Reducing calorie intake in laboratory animals results in a longer lifespan.
Older Ames dwarf mice perform better than normal mice of the same age on memory tests that measure retention of learned avoidance behavior, regardless of what they eat.
Aging mice that eat fewer calories move more than aging mice that eat without restriction, no matter their genetic makeup.
Ames dwarf mice eat more food relative to their body weight than normal mice, even when food is freely available, and their longer lifespan is not caused by eating less but may result from differences in how their bodies use energy.
Ames dwarf mice live longer than normal mice when both are fed freely, with 74% of dwarf mice surviving to 2.25 years compared to 27% of normal mice.