In healthy adult men, eating a diet very high in fat for a few days raises levels of a blood protein called apolipoprotein A-IV, while eating a diet very high in carbohydrates lowers it.

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Evidence from Studies

Supporting (1)

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Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism

Randomized Controlled Trial

Human & Animal & In Vitro

2025 May

Eating a lot of fat for a few weeks makes a protein called apoA-IV go up in your blood, while eating a lot of carbs makes it go down — so fat helps make this helpful protein, just like the claim says.

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Source Study

Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism

Score: 44

DOI: 10.1016/j.molmet.2025.102119

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