Why eating fat might help your blood sugar
Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
ApoA-IV lowers blood sugar without increasing insulin levels at rest.
Most blood sugar treatments force insulin up all the time, leading to resistance. This protein only activates insulin when glucose is present—like a smart switch, not a faucet.
Practical Takeaways
If you're struggling with blood sugar spikes or cravings, try replacing one high-carb meal per day with a high-fat, moderate-protein meal (e.g., eggs + avocado + salmon + olive oil).
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
ApoA-IV lowers blood sugar without increasing insulin levels at rest.
Most blood sugar treatments force insulin up all the time, leading to resistance. This protein only activates insulin when glucose is present—like a smart switch, not a faucet.
Practical Takeaways
If you're struggling with blood sugar spikes or cravings, try replacing one high-carb meal per day with a high-fat, moderate-protein meal (e.g., eggs + avocado + salmon + olive oil).
Publication
Journal
Molecular Metabolism
Year
2025
Authors
Annemarie Lundsgaard, R. Del Giudice, J. M. Kanta, M. Larance, S. Armour, Amalie London, M. Richter, N. R. Andersen, T. S. Nicolaisen, Christian S. Carl, K. Sjøberg, K. N. Bojsen-Møller, Jakob G. Knudsen, J. Lagerstedt, A. Fritzen, Bente Kiens
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Claims (6)
In obese mice, injecting apolipoprotein A-IV changes the levels of certain liver proteins involved in lipid transport, increasing those that help clear lipoproteins and decreasing those linked to artery disease, which may improve how the body processes fats.
In obese mice, a single injection of a specific human protein called apolipoprotein A-IV lowers blood sugar levels by about half within two hours by enhancing glucose uptake in fat tissues and decreasing glucose output from the liver, without involving insulin.
In healthy adult men, eating a diet very high in fat for a few days raises levels of a blood protein called apolipoprotein A-IV, while eating a diet very high in carbohydrates lowers it.
In obese mice, injecting apolipoprotein A-IV leads to a 220% increase in insulin release and a 140% increase in C-peptide during a glucose tolerance test, suggesting a direct enhancement of insulin production by pancreatic beta cells.
In obese mice, injecting apolipoprotein A-IV leads to higher fat burning and a 44% reduction in food consumption within 24 hours, which causes weight loss over eight days mainly because the mice eat less, not because they burn more energy.