When men with BRCA2 mutations get prostate cancer, it’s often more aggressive and shows up earlier in life than in men without the mutation.

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Evidence from Studies

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Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations

Narrative Review

2023 Apr

Men with a BRCA2 gene mutation are more likely to get a serious, fast-growing form of prostate cancer that’s harder to treat, and this study shows that clearly.

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Source Study

Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations

Score: 1

DOI: 10.1038/s41585-022-00680-4

Similar Assertions

Men who inherit a faulty BRCA2 gene are 2 to 4 times more likely to get prostate cancer than men without it.

1

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92%

Germline mutations in BRCA1 and BRCA2 genes confer a significantly elevated risk of developing prostate cancer in men, independent of family history of prostate cancer.

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87%

Having a BRCA1 mutation raises prostate cancer risk, but not as much as having a BRCA2 mutation.

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78%