If your family has BRCA gene mutations linked to breast or ovarian cancer, you’re at higher risk for prostate cancer too.
Scientific Claim
Germline mutations in BRCA1 and BRCA2 genes confer a significantly elevated risk of developing prostate cancer in men, independent of family history of prostate cancer.
Original Statement
“Mutations in the BRCA1 and BRCA2 genes which are well known in the context of breast and ovarian cancer in women also significantly increase prostate cancer risk in men. If you have a family history of those cancers, then that's relevant to your prostate cancer risk and it's worth discussing with your doctor.”
Context Details
Domain
oncology
Population
human
Subject
BRCA1 and BRCA2 germline mutations
Action
increase risk
Target
prostate cancer development in men
Intervention Details
Evidence from Studies
Supporting (1)
Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations
Men with inherited BRCA1 or BRCA2 gene mutations are much more likely to get prostate cancer, even if no one else in their family has had it — the study shows this risk is real and not just because of family history.