Having a BRCA1 mutation raises prostate cancer risk, but not as much as having a BRCA2 mutation.

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Evidence from Studies

Supporting (1)

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Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations

Narrative Review

2023 Apr

This study found that men with BRCA2 gene mutations are much more likely to get aggressive prostate cancer than men with BRCA1 mutations, but both groups still have higher risk than men without either mutation. So yes, BRCA2 is riskier than BRCA1.

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations

Score: 1

DOI: 10.1038/s41585-022-00680-4

Similar Assertions

Germline mutations in BRCA1 and BRCA2 genes confer a significantly elevated risk of developing prostate cancer in men, independent of family history of prostate cancer.

1

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89%

Men who inherit a faulty BRCA2 gene are 2 to 4 times more likely to get prostate cancer than men without it.

1

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87%

When men with BRCA2 mutations get prostate cancer, it’s often more aggressive and shows up earlier in life than in men without the mutation.

1

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78%

We don’t yet know if screening men with BRCA mutations for prostate cancer actually saves lives or improves how they feel long-term.

1

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76%

People with rare harmful changes in the BRCA1 or BRCA2 genes tend to live shorter lives, mostly because they’re more likely to get cancers like breast and ovarian cancer.

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74%