When mice swallow hyaluronan, only about 1 in 500 parts of it actually gets into their body without breaking apart—so most of it just passes through without being absorbed.
Claim Language
Language Strength
definitive
Uses definitive language (causes, prevents, cures)
The claim uses 'has' to assert a specific, precise value (0.2%) as a factual measurement, which implies certainty rather than possibility or association.
Context Details
Domain
nutrition
Population
animal
Subject
Orally administered hyaluronan
Action
has
Target
a bioavailability of approximately 0.2% in mice
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid.
The study found that when mice eat hyaluronan, almost none of it gets into their body as whole molecules — only tiny broken pieces do. This matches the claim that very little of it is absorbed.