When mice were given a daily shot of a peptide called MOTS-c, their bodies became better at using sugar for energy and responding to insulin, especially in their muscles.

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial

Animal

2015 Mar 3

The study shows that a tiny molecule from mitochondria, called MOTS-c, helps mice use sugar better and become less resistant to insulin, especially in their muscles—exactly what the claim says.

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Source Study

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Score: 13

DOI: 10.1016/j.cmet.2015.02.009

Similar Assertions

After a week of MOTS-c injections, mice could process insulin better, needing 30% more glucose to keep blood sugar stable during a test.

85%

When mice ate a high-fat diet, daily MOTS-c injections helped them stay lighter than untreated mice, even though they ate the same amount of food.

77%

Diabetic rats given MOTS-c had lower blood sugar levels after fasting, showing better control of glucose.

75%

Obese mice given MOTS-c injections for three days had lower blood sugar levels than mice that didn't receive the treatment.

75%

MOTS-c made muscle cells produce more GLUT4 (a sugar transporter) and turned on AMPK (an energy sensor), two key players in how muscles use sugar.

74%