When people took the supplement once, they ate about 14% less food at their next meal and had higher levels of gut hormones that make you feel full.
Scientific Claim
Acute ingestion of 10g inulin-propionate ester significantly increased postprandial plasma PYY and GLP-1 levels and reduced energy intake by 13.8% compared to control in healthy volunteers.
Source Excerpt
“Acute supplementation with inulin-propionate ester significantly reduced food intake from 1175 kcal (95% CI 957 to 1392) to 1013 kcal (95% CI 816 to 1210) (figure 2A, B; p<0.01), a mean reduction of 13.8%. It significantly increased plasma PYY (ΔAUC240–420 min 429 min×pmol/L (95% CI −543 to 1400) inulin-control vs 3349 min×pmol/L (841 to 5857) inulin-propionate ester, p<0.05) and GLP-1 levels (ΔAUC240–420 min 3495 min×pmol/L (95% CI −1567 to 8558) inulin-control vs 10 801 min×pmol/L (5897 to 15 704) inulin-propionate ester, p<0.05) between 240 min and 420 min.”
Evidence from Studies
Supporting Studies
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
The study used a randomised cross-over design to compare acute effects of the supplement versus control, showing statistically significant differences in gut hormone levels and energy intake. The design allows for comparison between intervention and control conditions.