Consuming high amounts of phytate, a compound found in plant foods, is linked to more zinc being eliminated in feces and less in urine, suggesting that phytate limits how much zinc the body absorbs...
Mechanism
Synthesis from 1 study
Phytate in food grabs onto zinc in your gut and makes it stuck together in a form your body can't absorb. So the zinc just passes through and comes out in your poop instead of entering your blood. With less zinc in your blood, your kidneys have less to get rid of, so you pee out less of it.
Most probable mechanism
When phytate is eaten with zinc-rich foods, it binds tightly to zinc in the gut, forming a solid clump that the body can't absorb. This means the zinc passes through the intestines and leaves the body in stool instead of entering the bloodstream. Because less zinc gets into the blood, the kidneys have less to filter out, so less zinc shows up in urine.
Phytate dissociates in the intestinal lumen and binds to free zinc ions, forming an insoluble complex.
The phytate-zinc complex cannot be transported across the intestinal epithelial cell membrane due to its insolubility and lack of affinity for zinc transporters.
Reduced zinc uptake by intestinal cells decreases the amount of zinc entering the bloodstream.
Lower systemic zinc levels result in reduced filtration and excretion of zinc by the kidneys, leading to decreased urinary zinc output.
Evidence from Studies
Supporting (1)
Community contributions welcome
A stable isotope study of zinc absorption in young men: effects of phytate and alpha-cellulose.
Contradicting (0)
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