When the adenosine A2A receptor is activated in neuronal cells, it increases the activity of glucocorticoid receptors in regulating gene expression. When this receptor is blocked, glucocorticoid...

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Supporting (1)

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The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Cohort Study

Animal

2016 Aug 11

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No contradicting evidence found

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Source Study

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Score: 8

DOI: 10.1038/srep31493

Similar Assertions

In rats, increasing the number of adenosine A2A receptors in the hippocampus makes the brain more responsive to stress hormones like dexamethasone, leading to a reduction in synaptic strengthening after short hormone exposure, but only in rats with elevated receptor levels.

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