In rats, increasing the number of adenosine A2A receptors in the hippocampus makes the brain more responsive to stress hormones like dexamethasone, leading to a reduction in synaptic strengthening...

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The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Cohort Study

Animal

2016 Aug 11

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Source Study

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Score: 8

DOI: 10.1038/srep31493

Similar Assertions

When the adenosine A2A receptor is activated in neuronal cells, it increases the activity of glucocorticoid receptors in regulating gene expression. When this receptor is blocked, glucocorticoid receptor activity decreases, even without added glucocorticoid hormones.

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In rats with elevated levels of adenosine A2A receptors, a drug called KW6002 that blocks these receptors restores normal function in brain regions involved in memory and synaptic communication.

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In rats, increasing the number of adenosine A2A receptors in specific brain regions interferes with the natural daily rhythm of stress hormones and reduces the presence of hormone receptors in the memory-related part of the brain, patterns that are also seen in aging and may be linked to memory problems.

73%

In rats, increasing the levels of a specific receptor called adenosine A2A interferes with the daily hormonal cycle of corticosterone and reduces the activity of genes in the hippocampus that help regulate stress responses and neuron survival.

72%