In rats, increasing the number of adenosine A2A receptors in specific brain regions interferes with the natural daily rhythm of stress hormones and reduces the presence of hormone receptors in the...

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The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Cohort Study

Animal

2016 Aug 11

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Source Study

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Score: 8

DOI: 10.1038/srep31493

Similar Assertions

In rats, increasing the levels of a specific receptor called adenosine A2A interferes with the daily hormonal cycle of corticosterone and reduces the activity of genes in the hippocampus that help regulate stress responses and neuron survival.

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In rats, increasing the number of adenosine A2A receptors in the hippocampus makes the brain more responsive to stress hormones like dexamethasone, leading to a reduction in synaptic strengthening after short hormone exposure, but only in rats with elevated receptor levels.

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