In rats, increasing the levels of a specific receptor called adenosine A2A interferes with the daily hormonal cycle of corticosterone and reduces the activity of genes in the hippocampus that help...

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The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Cohort Study

Animal

2016 Aug 11

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No contradicting evidence found

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Source Study

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Score: 8

DOI: 10.1038/srep31493

Similar Assertions

In rats, increasing the number of adenosine A2A receptors in specific brain regions interferes with the natural daily rhythm of stress hormones and reduces the presence of hormone receptors in the memory-related part of the brain, patterns that are also seen in aging and may be linked to memory problems.

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In rats, increasing the number of adenosine A2A receptors in the hippocampus makes the brain more responsive to stress hormones like dexamethasone, leading to a reduction in synaptic strengthening after short hormone exposure, but only in rats with elevated receptor levels.

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