When your body doesn't have enough nitric oxide—a molecule that helps blood vessels relax—it seems to make a group of related health problems like diabetes, kidney issues, and heart trouble get worse.

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Evidence from Studies

Supporting (1)

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Addressing the “Nitric Oxide Crisis” in Cardiovascular–Kidney–Metabolic Syndrome: Therapeutic Potential of the Inorganic Nitrate–Nitrite–NO Pathway

Narrative Review

Human

2026 Feb

The study shows that when the body doesn’t have enough nitric oxide, it makes heart, kidney, and metabolism problems worse — and giving certain harmless nitrates (like in beets) can help fix that.

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Source Study

Addressing the “Nitric Oxide Crisis” in Cardiovascular–Kidney–Metabolic Syndrome: Therapeutic Potential of the Inorganic Nitrate–Nitrite–NO Pathway

Score: 1

DOI: 10.1111/obr.70021

Similar Assertions

As people get older, their bodies make less of a helpful molecule called nitric oxide, which makes it harder for blood vessels to work properly — and this can cause problems in the heart, brain, reproductive organs, and muscles.

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Chronic insulin resistance impairs endothelial function by reducing nitric oxide production, leading to arterial stiffness and increased vascular resistance.

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In healthy adults, insulin doesn't make blood vessels relax more when nitric oxide is already at work — meaning insulin probably doesn't improve blood flow by boosting the muscle's response to nitric oxide.

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