If you lift heavy weights for fewer reps and lighter weights for more reps but do the same total work, you'll build about the same muscle size, but you'll get stronger faster with the heavy weights.
Evidence from Studies
Supporting (2)
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Effects of Different Volume-Equated Resistance Training Loading Strategies on Muscular Adaptations in Well-Trained Men
The study looked at two workout styles with the same total work: one with few heavy lifts and one with many lighter lifts. It found both built similar muscle size, but the heavy-lift group got stronger faster, just like the claim said.
Muscle hypertrophy and strength gains after resistance training with different volume matched loads: a systematic review and meta-analysis.
The study shows that lifting heavier weights fewer times (like 3 reps) makes you stronger than lifting lighter weights more times (like 10 reps) when the total work is the same, but both ways build muscle equally.
Contradicting (2)
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Comparing High-Load and Low-Load Endurance Training for Strength and Hypertrophy: A Systematic Review and Meta-Analysis
The study talks about heavy weights and light weights in general, but it doesn't specifically test the exact rep ranges or equal workout volume like the claim does, so it can't confirm or deny the claim.
Divergent Strength Gains but Similar Hypertrophy After Low-Load and High-Load Resistance Exercise Training in Trained Individuals: Many Roads Lead to Rome.
The study compared 3-5 reps with 20-25 reps, not 3 reps with 10 reps as the claim states, so it doesn't directly test the same thing.
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.