The Claim

In young adult males undergoing energy deficit, ingestion of 0.3 g/kg of essential amino acids results in significantly higher circulating concentrations of essential amino acids compared to ingestion of 0.1 g/kg of essential amino acids.

Source: Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
72score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Quantitative
1 study reviewed
In plain English

When young adult men are in a calorie-deficient state, consuming 23.5 grams of essential amino acids leads to higher levels of these amino acids in the blood than consuming 7.87 grams.

See the scientific wording

In young adult males undergoing energy deficit, circulating essential amino acid concentrations are significantly higher after ingestion of 0.3 g/kg (23.5 g) compared to 0.1 g/kg (7.87 g) of essential amino acids, indicating dose-dependent absorption and bioavailability.

Why this might work

When a larger amount of essential amino acids is swallowed, more of them get absorbed through the gut lining because the transporters that move them into the blood become fully occupied and work at maximum speed. This causes more amino acids to enter the bloodstream compared to when a smaller amount is taken, where the transporters are not fully used.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study.

    When young men eat fewer calories, drinking a shake with 23.5 grams of essential amino acids makes more of those amino acids show up in their blood than drinking a shake with only 7.87 grams — the study directly measured this and found it to be true.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.