With only 8 pigs, the study couldn't detect tiny differences, but any differences seen were too small to matter in real life.
Scientific Claim
The study's small sample size (n=8 minipigs) limited statistical power, but the observed differences between collagen scaffold-augmented and suture-only ACL repairs were clinically insignificant.
Original Statement
“Due to the expenses of large animal studies, the number of knees in each study group was relatively low (n=8). This can raise concerns about low power in a study in which no significant difference is detected between groups. However, the differences between the SCAFFOLD and SUTURE groups were not only statistically insignificant, they were likely to be clinically insignificant given the small changes between means of the two groups.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The claim directly quotes the study's self-assessment of sample size and clinical relevance without overinterpretation.
Evidence from Studies
Supporting (1)
Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament