If you're losing weight with retatrutide but not eating enough protein or doing strength training, you might lose a lot of muscle because your body starts breaking it down.

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Evidence from Studies

Supporting (1)

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Incretin-Based Weight Loss Pharmacotherapy: Can Resistance Exercise Optimize Changes in Body Composition?

Narrative Review

Human

2024 Oct 1

The study shows that weight-loss drugs like retatrutide cause muscle loss, and that exercise can help prevent it. This supports the idea that without enough protein and strength training, you could lose a lot of muscle on these drugs.

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Similar Assertions

People with obesity who took a shot called retatrutide once a week for a year lost nearly a quarter of their body weight—way more than those who got a dummy shot. This makes it one of the strongest weight-loss medicines we’ve seen so far.

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Retatrutide keeps helping people lose weight steadily for a whole year without slowing down, while other weight-loss drugs like GLP-1s tend to stop working as well after a few months.

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