Assertion

Fasting can induce autophagy and promote cellular cleaning.

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Explained

Fasting has been shown to induce autophagy, which can help promote cellular cleaning and remove damaged or dysfunctional cellular components. This can lead to improved cellular health and reduced inflammation.

Context for Assertion

Fasting has been shown to have various health benefits, including improved insulin sensitivity and reduced inflammation.

Concepts for Assertion

Fasting

The act of abstaining from food and drink for a period of time, which can have various health benefits.

Tags

fasting
autophagy
cellular health

Evidence for Assertion

Why relevant:
Why true:The study shows that fasting activates autophagy, which is tied to the cellular cleaning process.
How it is true:The research conducted an experiment showing that neuronal autophagy increases during fasting, confirming the assertion.
ELI5
  • The researchers looked at brain cells during fasting.
  • They found that fasting made the cells clean themselves by increasing autophagy.
  • This means fasting helps cells get rid of junk, supporting the idea that fasting is effective for cellular health.
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Short-term fasting induces profound neuronal autophagy
Study Type:Animal Study
DOI:N/a
Experimental Study
Animal
n=20
p≤0.05
Autophagy
Publication 16/08/2010
Why relevant:
Why true:It measures how fasting leads to increases in cellular processes responsible for cleaning.
How it is true:The study directly examined the effects of fasting, showing significant increases in autophagy and mitophagy.
ELI5
  • The scientists studied people who fasted to see what happened in their bodies.
  • They found that fasting increased both autophagy and mitophagy, which are ways cells clean up.
  • This shows that fasting really does help in getting rid of unwanted cell parts, confirming the claim.
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The effect of fasting or calorie restriction on mitophagy induction: a literature review
Study Type:Other Study
DOI:N/a
Review Article
Other
Journal of Cachexia, Sarcopenia and Muscle
Publication 27/08/2020
Why relevant:
Why true:It explores how fasting influences cellular mechanisms for autophagy.
How it is true:The research found that fasting is crucial for triggering autophagy through specific biochemical pathways.
ELI5
  • Researchers looked into how fasting affects a molecule called spermidine.
  • They discovered that spermidine is vital for starting the process of cellular cleaning during fasting because it increases autophagy.
  • This means fasting not only prompts cleaning mechanisms but shows how these processes work at a chemical level.
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Spermidine is essential for fasting-mediated autophagy and longevity
Study Type:Human Study
DOI:N/a
Experimental Study
Human
n=161
p≤0.05
Nature Cell Biology
Publication 01/08/2024

Assertion from content

New Research Finds How to Increase Autophagy Without Fasting (6 different types)
“fasting is going to make us more efficient”